Assessing Project Suitability for Off-site Production

Implementation of off-site production on construction projects isoften hindered by a number of specific process and procurementconstraints. These constraints are largely influenced by decisionswithin the control of construction clients, suggesting that theyhave a significant influence over the adoption of off-site productioninto construction projects. However, an appreciation of the effectof these constraints has been lacking. Addressing this need, anoff-site production implementation assessment instrument thatresides within a larger toolkit (IMMPREST) was developed usingquestionnaire survey data and a series of industrial workshops.IMMPREST is an interactive electronic toolkit developed byLoughborough University (UK), in conjunction with eleven industrialpartners, which facilitates the evaluation of benefit arising fromuse of off-site production within construction. It identifies thefactors that need to be considered for an evaluation, the datarequired to assess the effect of these factors, and where therequired data resides within the supply chain. Development ofthe implementation assessment instrument is discussed, whilstalso making reference to the role that clients can play in creatingthe process and procurement conditions that promote rather thanconstrain the adoption of off-site production

Governmentality and exclusion in post-disaster spaces : conducting the conduct of the survivors of Typhoon Sendong in Cagayan de Oro, Philippines

Lorsque les aléas naturels se déroulent en catastrophes, les réponses des religieux, de l’Etat, et d’autres acteurs puissants dans une société révèlent à la fois les relations complexes entre ces parties et leur pouvoir dans la production des espaces auxquelles les survivants accèdent. La réponse en cas de catastrophe comprend la création d’espaces post-catastrophes, tels que des centres d’évacuation, des logements de transition et des sites de réinstallation permanente, qui ciblent spécifiquement un sous-ensemble particulier de survivants, et visent à les aider à survivre, à faire face, et à se remettre de la catastrophe. Les acteurs puissants dans une société dirigent les processus de secours, de récupération et de reconstruction sont des acteurs puissants qui cherchent à problématiser et à rendre un problème technique dans des termes qu’ils sont idéalement placés pour aborder à travers une variété d'interventions. Ce projet de recherche vise à répondre à la question: où les survivants d'une catastrophe reconstruisent-ils leurs vies et leurs moyens de subsistance? Il enquête sur un cas spécifique de la migration environnementale dans laquelle des dizaines de milliers d'habitants ont été déplacés de façon permanente et temporaire de leurs résidences habituelles après le typhon Sendong à Cagayan de Oro, Philippines en 2011. La recherche est basée sur des entretiens avec les acteurs puissants et les survivants, des vidéos participatives réalisées par des survivants pauvres urbains, et des activités de cartographie. L’étude se fonde sur la théorie féministe, les études de migration, les études dans la gouvernementalité, la recherche sur les changements de l’environnement planétaire, et les études régionales afin de situer les diverses expériences de la migration dans un contexte géographique et historique. Cette thèse propose une topographie critique dans laquelle les processus et les pratiques de production d’espaces post-catastrophe sont exposés. Parce que l’espace est nécessairement malléable, fluide, et relationnelle en raison de l'évolution constante des activités, des conflits, et des expériences qui se déroulent dans le paysage, une analyse de l'espace doit être formulée en termes de relations sociales qui se produisent dans et au-delà de ses frontières poreuses. En conséquence, cette étude explore comment les relations sociales entre les survivants et les acteurs puissants sont liées à l’exclusion, la gouvernementalité, la mobilité, et la production des espaces, des lieux et des territoires. Il constate que, si les trajectoires de migration de la plupart des survivants ont été confinés à l'intérieur des limites de la ville, les expériences de ces survivants et leur utilisation des espaces urbains sont très différentes. Ces différences peuvent être expliquées par des structures politiques, économiques, et sociales, et par les différences religieuses, économiques, et de genre. En outre, il fait valoir que les espaces post-catastrophe doivent être considérés comme des «espaces d’exclusion» où les fiduciaires exercent une rationalité gouvernementale. C’est-à-dire, les espaces post-catastrophe prétendument inclusives servent à marginaliser davantage les populations vulnérables. Ces espaces offrent aussi des occasions pour les acteurs puissants dans la société philippine d'effectuer des interventions gouvernementales dans lesquelles certaines personnes et les paysages sont simplifiées, rendues lisibles, et améliorés.When natural hazards unfold into disasters, the responses of religious, state, and other trustees reveal both the complex relationships among these parties and their power in producing the spaces accessed by the survivors. The disaster response includes the creation of post-disaster spaces, such as evacuation centres, transitional housing, and permanent resettlement sites, that specifically target or appeal to a particular subset of survivors, and aim to help them to survive, to cope with, and to recover from the disaster. The trustees directing the processes of disaster relief, recovery, and rebuilding are powerful actors who seek to problematise and render technical an issue in terms that they are ideally placed to address through a variety of interventions. This research project sets out to answer the question: where do the survivors of a disaster rebuild their lives and livelihoods? It investigates a specific case of environmental migration in which tens of thousands of residents were permanently and temporarily displaced from their usual places of residence after Typhoon Sendong in Cagayan de Oro, Philippines in 2011. The research is based on interviews with trustees and survivors, participatory videos made by urban poor survivors, and mapping activities. The study draws on feminist theory, migration studies, studies in governmentality, global environmental change literature, and regional studies to situate diverse experiences of migration within a geographical and historical context. This dissertation offers a critical topography in which the processes and practices of producing post-disaster spaces are exposed. Because space is necessarily malleable, fluid, and relational due to the ever-changing activities, conflict, and experiences unfolding in the landscape, any analysis of space must be formulated in terms of the social relations occurring within and beyond its porous boundaries. Accordingly, this study explores how the social relations among survivors and trustees are linked to exclusion, governmentality, mobility, and space- and place-making. It finds that although the migration trajectories of most survivors were confined within the city limits, the experiences of these survivors and their use of urban spaces were vastly different. These differences can be explained by political, economic, and social structures, and by religious, economic, and gender differences. Furthermore, it argues that post-disaster spaces are best understood as “spaces of exclusion” where trustees exercise a governmental rationality. That is, purportedly inclusive post-disaster spaces serve to further marginalise vulnerable populations. These spaces also open opportunities for trustees to carry out governmental interventions in which certain people and landscapes are simplified, rendered legible, and improved

Benefit evaluation for off-site production in construction

Evaluating to what extent a component or building system should be produced offsite is inadequate within the industry. The potential benefits of off-site production (OSP) are commonly cited when justifying an OSP approach, yet holistic and methodical assessments of the applicability and overall benefit of these solutions, to a particular project, have been found to be deficient. Common methods of evaluation simply take material, labour and transportation costs into account when comparing various options, often disregarding other cost-related items such as site facilities, crane use and rectification of works. These cost factors are usually buried within the nebulous preliminaries figure, with little reference to the building approach taken. Further, softer issues such as health and safety, effects on management and process benefits are either implicit or disregarded within these comparison exercises. Yet it is demonstrated that these issues are some of the most significant benefits of OSP. A series of case studies demonstrated that evaluation focus is almost solely on direct material and labour costs of components, without explicit regard for the wider cost or soft issue implications of OSP on a project. The paper argues that until evaluation is more holistic and value-based rather than cost-based, OSP uptake in construction will be slow

A paradigm shift towards Whole Life Analysis in adaptable buildings

Economic evaluation is a significant consideration in the initiation of a facility. This evaluation process should take into account all costs, benefits and performance associated with a facility in its through life cycle. There are a number of techniques available for economic evaluation, however, the practical application is poor in most of the techniques. Whole Life Analysis (WLA) is identified as a comprehensive approach for economic evaluation. At present there is a growing trend towards designing buildings to be more adaptable within the UK property market. Hence, economic evaluation of adaptable buildings needs to be undertaken as early as possible for appropriate long term decisions. This paper examines the paradigm shift required for a WLA approach for adaptable buildings while identifying the benefits and barriers of its practical application. A comprehensive literature review was undertaken to analyse how WLA could be used as a decision support technique for adaptable buildings. Literature reveals WLA as one of the best decision support techniques for use in the building industry, and it seems logical to adopt it for adaptable buildings. However, detailed economic evaluation remains an untapped area within adaptable buildings. Being involved in the ‘Adaptable Futures’ research project at Loughborough University, the authors have blended their thoughts with available literature and attempt to identify how important in undertaking WLA is for an adaptable facility while identifying the barriers of current applications. Stakeholder input is crucial towards the betterment of WLA particularly concerning its understanding and application in adaptable buildings

Towards economic sustainability through adaptable buildings

The existing building stock in most countries does not meet the parameters of economic, social and environmental sustainability. Physical, functional, technological, economical, social and legal obsolescence are the principal factors driving the decommissioning, refurbishment, alteration and/or adaptation of a building. In the UK the Government promotes optimum use of the existing building stock through mixed use in urban centers and encourages conversion of redundant office and retail space into leisure, service and/or residential uses rather than demolition and renewal. There is therefore a growing need to design new buildings that are adaptable and flexible over their life span whilst at the same time improving user satisfaction. A constraint to the implementation of a policy of life span adaptability is the difficulty of understanding the economic considerations over long time scales. This paper investigates the issues surrounding the economics of the life span of adaptable buildings, and establishes a conceptual framework for their economic sustainability. The investigation is based on a case study of how the uses and function of the built environment and its supporting infrastructure have changed over a period of 100 years undertaken within a semi-rural Borough in England, UK. This case study includes a trend analysis identifying the life spans (of buildings), the evolving planning policies and associated social and cultural issues. A conceptual framework is developed and the economic impacts of the changes are evaluated through Whole Life Analysis. The validity and reliability of proposed framework is yet to be tested

OFF-SITE PRODUCTION: EVALUATING THE DRIVERS AND CONSTRAINTS

ABSTRACT The decision making process used to evaluate to what extent a component or building system should be produced off-site is inadequate within the industry. Whilst the potential benefits of off-site production (OSP) are commonly cited when justifying an OSP approach, no clear method for assessing the applicability and overall benefit of these solutions exist. Common methods of evaluation simply take material, labour and transportation costs into account when comparing various options, often disregarding other cost-related items such as site facilities, crane use and rectification of works. These cost factors are usually buried within the nebulous preliminaries figure, with little reference to the building approach taken. Further, softer issues such as health and safety, effects on management and process benefits are either implicit or disregarded within these comparison exercises. Additionally, the factors that affect the suitability of OSP as a design solution are not formally defined, these are the factors that drive and/or constrain the design decision making

Towards economic sustainability through adaptable buildings

The existing building stock in most countries does not meet the parameters of economic, social and environmental sustainability. Physical, functional, technological, economical, social and legal obsolescence are the principal factors driving the decommissioning, refurbishment, alteration and/or adaptation of a building. In the UK the Government promotes optimum use of the existing building stock through mixed use in urban centers and encourages conversion of redundant office and retail space into leisure, service and/or residential uses rather than demolition and renewal. There is therefore a growing need to design new buildings that are adaptable and flexible over their life span whilst at the same time improving user satisfaction. A constraint to the implementation of a policy of life span adaptability is the difficulty of understanding the economic considerations over long time scales. This paper investigates the issues surrounding the economics of the life span of adaptable buildings, and establishes a conceptual framework for their economic sustainability. The investigation is based on a case study of how the uses and function of the built environment and its supporting infrastructure have changed over a period of 100 years undertaken within a semi-rural Borough in England, UK. This case study includes a trend analysis identifying the life spans (of buildings), the evolving planning policies and associated social and cultural issues. A conceptual framework is developed and the economic impacts of the changes are evaluated through Whole Life Analysis. The validity and reliability of proposed framework is yet to be tested

Modular assembly with postponement to improve health, safety, and productivity in construction

This paper presents the outcome of an engineering study as part of the design and development of a lean and agile construction system and in particular its supply chain component. This combines modular assembly with a postponement function to be tested on a case study project (not reported here), the objective of which is to improve health, safety, and productivity for the company sponsoring the research. The contribution to research is the combination of countermeasures described in this paper that have been developed and incorporated into a wider construction system, in the same way that manufacturing has used this strategy with great success. A further output is the development and use of an innovative method for assembling, transporting, and installing mechanical and electrical modules, whereby modularization can be achieved with or without offsite manufacturing capability. The research forecasts a reduction of onsite labor of 35% compared to using traditional methods of construction, with less onsite operatives at risk of injury carrying out simpler assembly tasks within ergonomic mobile work cells. Further research is proposed to measure the benefits of the construction system following its implementation on a case study project

Prevalence and effect of pre-treatment drug resistance on the virological response to antiretroviral treatment initiated in HIV-infected children - a EuroCoord-CHAIN-EPPICC joint project.

Few studies have evaluated the impact of pre-treatment drug resistance (PDR) on response to combination antiretroviral treatment (cART) in children. The objective of this joint EuroCoord-CHAIN-EPPICC/PENTA project was to assess the prevalence of PDR mutations and their association with virological outcome in the first year of cART in children. HIV-infected children <18 years initiating cART between 1998 and 2008 were included if having at least one genotypic resistance test prior to cART initiation. We used the World Health Organization 2009 resistance mutation list and Stanford algorithm to infer resistance to prescribed drugs. Time to virological failure (VF) was defined as the first of two consecutive HIV-RNA > 500 copies/mL after 6 months cART and was assessed by Cox proportional hazards models. All models were adjusted for baseline demographic, clinical, immunology and virology characteristics and calendar period of cART start and initial cART regimen. Of 476 children, 88 % were vertically infected. At cART initiation, median (interquartile range) age was 6.6 years (2.1-10.1), CD4 cell count 297 cells/mm(3) (98-639), and HIV-RNA 5.2 log10copies/mL (4.7-5.7). Of 37 children (7.8 %, 95 % confidence interval (CI), 5.5-10.6) harboring a virus with ≥1 PDR mutations, 30 children had a virus resistant to ≥1 of the prescribed drugs. Overall, the cumulative Kaplan-Meier estimate for virological failure was 19.8 % (95 %CI, 16.4-23.9). Cumulative risk for VF tended to be higher among children harboring a virus with PDR and resistant to ≥1 drug prescribed than among those receiving fully active cART: 32.1 % (17.2-54.8) versus 19.4 % (15.9-23.6) (P = 0.095). In multivariable analysis, age was associated with a higher risk of VF with a 12 % reduced risk per additional year (HR 0.88; 95 %CI, 0.82-0.95; P < 0.001). PDR was not significantly associated with a higher risk of VF in children in the first year of cART. The risk of VF decreased by 12 % per additional year at treatment initiation which may be due to fading of PDR mutations over time. Lack of appropriate formulations, in particular for the younger age group, may be an important determinant of virological failure

A Cross-Study Transcriptional Analysis of Parkinson's Disease

The study of Parkinson's disease (PD), like other complex neurodegenerative disorders, is limited by access to brain tissue from patients with a confirmed diagnosis. Alternatively the study of peripheral tissues may offer some insight into the molecular basis of disease susceptibility and progression, but this approach still relies on brain tissue to benchmark relevant molecular changes against. Several studies have reported whole-genome expression profiling in post-mortem brain but reported concordance between these analyses is lacking. Here we apply a standardised pathway analysis to seven independent case-control studies, and demonstrate increased concordance between data sets. Moreover data convergence increased when the analysis was limited to the five substantia nigra (SN) data sets; this highlighted the down regulation of dopamine receptor signaling and insulin-like growth factor 1 (IGF1) signaling pathways. We also show that case-control comparisons of affected post mortem brain tissue are more likely to reflect terminal cytoarchitectural differences rather than primary pathogenic mechanisms. The implementation of a correction factor for dopaminergic neuronal loss predictably resulted in the loss of significance of the dopamine signaling pathway while axon guidance pathways increased in significance. Interestingly the IGF1 signaling pathway was also over-represented when data from non-SN areas, unaffected or only terminally affected in PD, were considered. Our findings suggest that there is greater concordance in PD whole-genome expression profiling when standardised pathway membership rather than ranked gene list is used for comparison